نتایج جستجو برای: Hypoxia inducible factors

تعداد نتایج: 1159240  

Journal: :iranian journal of basic medical sciences 0
fattah sotoodehnejadnematalahi department of regenerative biomedicine at cell science research center, royan institute for stem cell biology and technology, acecr, tehran, iran bernard burke department of infection, immunity and inflammation, university of leicester, leicester, le1 9hn, uk

macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods. up to date, different studies have shown that a number of transcription factors are activated by hypoxia which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro...

Bernard Burke, Fattah Sotoodehnejadnematalahi

Macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods. Up to date, different studies have shown that a number of transcription factors are activated by hypoxia which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro...

Journal: :Journal of Clinical Investigation 2020

Journal: :Molecular & Cellular Oncology 2016

Journal: :Current Sleep Medicine Reports 2017

Journal: :Cell 2015
Kyoung Eun Lee M. Celeste Simon

Molecular oxygen (O2) is a key substrate for mitochondrial ATP production and numerous intracellular biochemical reactions. The maintenance of O2 homeostasis is therefore essential for the survival of most species. During O2 deprivation, mammalian cells rely on multiple adaptations mediated by the hypoxia-inducible factors (HIFs), mTOR, autophagy, and the ER stress response. This SnapShot will ...

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